The naked mole rat, our model of longevity

The mole rat, like the animal of the same name, as ugly as blind, naked as "naked as a worm". He does not finish revealing his secrets ... He could be repulsive but the researchers pamper him. It is known that this rodent of 8 centimeters for 35 grams on average, lives perfectly well up to thirty years.

A rat dying of old age; No diseases

Thirty years, nothing extraordinary, because humans live on average much longer, except that compared to the average life of rats, 30 years is the equivalent of nearly 400 years for us. And that's where the performance becomes remarkable ...
It is therefore very interesting to discover the secret of this very particular youth, because this rat, in addition to living very, very old, lives also without diseases ... In fact, he dies very slowly; this is called old age death.
One might think he lives very old because he is never, or almost, sick - without the usual diseases of other rats; but it is in the intimate mechanism of the multiplication of its cells that the researchers have tried to understand. Oncologists provide the first answers. In fact, studies on the naked mole rat have shown that this rodent is resistant to tumor formation. No trace of cancer was found in the entire species.

Secretion of an anti-cancer drug

Researchers at the University of Rochester in the United States, who have tried to understand why this small rodent is much more resistant to cancer than its laboratory counterparts, the mice, believe they have unlocked the secret of its longevity: you know that Explanations of the occurrence of cancer is that our aging cells start to go crazy and secrete damaged products. Well, the proteins of this rat are 40% less likely to contain genetic errors and to make sick cells. This is the secret of its longevity.

This means that these rats somehow secrete their own anti-cancer drug, their own treatment, and these same researchers published a study in the British journal Nature. They showed that an acid present in the naked mole rat prevented cancer cells from clumping together and thus forming tumors ...

Hyaluronic acid

That those who think that rats will replace man on the surface of this planet may not be quite wrong ...

More practically, that this rodent can teach us a lot about the fight against the transformations of the tumors in the man, and particularly, offers a serious track against the formation of cancerous cells. Because we have identified the anti-cancer that makes this animal; it's called hyaluronic acid, a substance that people with osteoarthritis know well because they are regularly injected into the knee ...

The media are beginning to take an interest in this phenomenon of underground life. Arte even made the star of a documentary, "The Superpowers of the Naked Mole Rats," by Herbert Ostwald tonight at 22:20 and (available in replay).

All laboratories around the world that work on diseases related to aging but also on the mechanism of transformation of the normal cell into a cancer cell include work on this little rat full of promise. They promise us real advances in two years.

Video: The naked mole-rat's secret to eternal youth - World's Weirdest Event's: Episode 3 Preview - BBC Two (April 2020).