Fibromyalgia: networks of hypersensitive neurons in the brain

One study shows that fibromyalgia patients have networks of neurons in the brain that can react very quickly. This abnormal hypersensitivity, called explosive synchronization, can be observed in other network phenomena across nature.

Researchers at the University of Michigan report evidence of hypersensitivity of the neurological pathways of pain or "explosive timing" in the brains of people with fibromyalgia, a condition characterized by widespread chronic pain. This study is published in Scientific Reports.
« For the first time, this research shows that the hypersensitivity experienced by patients with chronic pain can result from hypersensitive brain networks "says Richard Harris, co-lead author of the study. " People had an arousal state of excitement of pain pathways similar to networks that undergo explosive synchronization. ". The researchers say this is a promising avenue to explore to determine how a person develops fibromyalgia.

Networks « electrically unstable »

Researchers recorded electrical activity in the brains of 10 patients with fibromyalgia. The results put forward hypersensitive and unstable neurological pathways in the brain, with an explosive response to any stimulation. It is important to note that there was a strong correlation between the degree of explosive timing and the self-reported intensity of chronic pain reported by patients.
« We see again that the brain of chronic pain is electrically unstable and sensitive Says Dr. Harris. This type of modeling could help guide future treatments for fibromyalgia since explosive synchronizations can be modeled outside the brain.

These regions of the brain could then be targeted with non-invasive brain modulation treatments.

Video: Nociceptors - An Introduction to Pain (March 2020).